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Browsing by Author "Qaisiya, Mohammed"

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The activation of autophagy protects neurons and astrocytes against bilirubin-induced cytotoxicity

Qaisiya, Mohammed (ELSEVIER - Neuroscience Letter, 2017-12-20)

Unconjugated bilirubin (UCB) neurotoxicity involves oxidative stress, calcium signaling and ER-stress. The same insults can also induce autophagy, a process of "self-eating", with both a pro-survival or a pro-apoptotic ...
Bilirubin disrupts calcium homeostasis in neonatal hippocampal neurons: a new pathway of neurotoxicity

Rauti, Rossana; Qaisiya, Mohammed; Tiribelli, Claudio; Ballerini, Laura; Bellarosa, Cristina (Springerlink, 2020-03-03)

Severe hyperbilirubinemia leads to bilirubin encephalopathy in neonates, causing irreversible neurological sequelae. We investigated the nature of neuronal selective vulnerability to unconjugated bilirubin (UCB) toxicity. ...
Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway

Qaisiya, Mohammed (ELSEVIER - Cellular Signaling, 2014-03-01)

Unconjugated bilirubin (UCB) is responsible for neonatal jaundice and high level of free bilirubin (Bf) can lead to kernicterus. Previous studies suggest that oxidative stress is a critical component of UCB-induced ...
Bilirubin-induced ER stress contributes to the inflammatory response and apoptosis in neuronal cells

Qaisiya, Mohammed (Springer - Archive of toxicology, 2016-08-30)

Unconjugated bilirubin (UCB) in newborns may lead to bilirubin neurotoxicity. Few studies investigated the activation of endoplasmic reticulum stress (ER stress) by UCB. We performed an in vitro comparative study using ...

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